Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Number of Components Comps. 1 15 U.S.C §2601 et seq. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Catalog Number Cat. 1989]. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation Reaction with water to form Carbon Dioxide [Merck 11th ed. <]>> Reduction in diisocyanate-related occupational asthma is primarily … Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. H315 Causes skin irritation. 26 0 obj<> endobj Reported as not meeting GHS hazard criteria by 1 of 1196 companies. when handling these materials. Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. Email. 0000003741 00000 n Certificate of Analysis COA. stream }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). 7.6 1,2,4-Trichlorobenzene (TCB). Baltimore, MD: The Williams and Wilkins Co., p. 141. Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! NZ Med J 63:642-647. View other preventive measures for 2,4-toluene diisocyanate in WISER. INTRODUCTION 14 III. Methyl Isocyanate. The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … [Handling Chemcials Safely 1980. p. 907]. 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. R. Schwalm, in Encyclopedia of Materials: Science and Technology, 2001 Methyl Isocyanate. 0000012275 00000 n Experimental studies in animals have demonstrated that toluene diisocyanate (TDI) is a carcinogen. Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. International Chemical Safety Cards (ICSC). Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. (January 1986). 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Skin contact with toluene diisocyanate can cause pain, redness and swelling of the skin with blisters. Gunter BJ [1975]. 0000001487 00000 n The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanate are two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. Risk of fire and explosion as a result of … Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … This is based on test results presently SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. 0000004899 00000 n View other preventive measures for 2,4-toluene diisocyanate in WISER. Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. endobj endobj 4 0 obj The main components are toluene-2,4-diisocyanate (2,4-TDI) and toluene-2,6-diisocyanate (2,6-TDI), for example in frequently used mixtures in the ratio of 80 % 2,4-TDI to 20 % 2,6-TDI (TDI 80/20) and 65 % 2,4-TDI to 35 % 2,6-TDI (TDI 65/35). 0000052031 00000 n Potential explosion if stored in polyethylene containers due to … # D-5836-02N. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Add to Cart Add. 0000003317 00000 n Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. Additional Information. 2,6-Toluene diisocyanate. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. Provide adequate ventilation and wear impermeable gloves (for example, rubber, polyethylene, etc.) Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. 7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. For more detailed information, please visit ECHA C&L website … Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). National Institute for Occupational Safety and Health (NIOSH). %PDF-1.5 %���� 0000006881 00000 n Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Methylene Bisphenyl Isocyanate. ���i�����LAװ�BjL���6� Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. 0000009752 00000 n eye contact: may cause eye irritation. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. Identification . The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. Compendium of Chemical Hazards: Toluene diisocyanate Page 3 of 4 General Information Ingestion of toluene diisocyanate may cause nausea, vomiting and abdominal pain. (February 1996). Toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are useful for polyurethane products. The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … startxref 77, No. Boiling points. Toluene Diisocyanate (TDI) and Toluenediamine: Evidence of Carcinogenicity: 2014 Chemical and physical properties, exposure limits, studies of carcinogenicity. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. 0000003775 00000 n 0000005710 00000 n Ambient (>5 °C) Safety Data Sheet SDS. Les isocyanates, notamment le toluène de diisocyanate (TDI), et l'hexaméthylène di-isocyanate (HDI) constituent la première cause d’asthme chimique professionnel. 0000007141 00000 n 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . * Many scientists believe there is no safe level of exposure to a carcinogen. 0000000016 00000 n Reaction with water to form Carbon Dioxide [Merck 11th ed. Compare. Viscosity @ 20°C Vapour pressure @ 20°C. Mutat Res 79:363-375. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. 0000001407 00000 n Login to download SDS . Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. Molecular Weight 174.16 . Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. Toluene Hazards & Safety Tips. * Many scientists believe there is no safe level of exposure to a carcinogen. 1 0 obj Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. Toluene Safety Data Sheet according to Federal Register / Vol. 0000008879 00000 n Isophorone Diisocyanate. Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. 0000010616 00000 n 0000008003 00000 n 0000004561 00000 n 0000004823 00000 n chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. Hazards Identification GHS-US classification Acute toxicity (inhal. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. (April 1996). 1.1. Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. 90-117. toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. 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